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In an interacting responses loop, CLOCK-BMAL1 complexes activate expression of nuclear receptors, REV-ERB ? and ROR?. Their protein products feed-back to manage BMAL1 by competitively binding retinoic acid-linked orphan receptor response things during the BMAL1 promoter40. REV-ERBs repress the transcription of BMAL1, Whilst RORs activate it. These